Clinical experience with Imdur in angina pectoris. A review

    Eur J Clin Pharmacol. 1990;38 Suppl 1:S65-8. doi: 10.1007/BF01417567.


    Imdur contains isosorbide-5-mononitrate (IS-5-MN) in a controlled-release (Durules) formulation. It has a significant anti-anginal effect when taken once daily at a dose of 60 mg. This anti-anginal effect persists during long-term treatment without the development of tolerance; once-daily treatment produces a plasma nitrate profile that is high enough to give anti-anginal protection during the daytime, but low enough during the latter part of the dosage interval to avoid the development of tolerance. Evidence shows that once-daily Imdur is equivalent in efficacy to plain tablets of IS-5-MN and isosorbide dinitrate taken three times daily at the same total daily dosage (60 mg), and to the calcium antagonist diltiazem (60 mg three times daily). In addition, the anti-anginal protection provided by Imdur in combination with beta-blocker treatment is superior to that achieved with beta-blocker treatment alone. In long-term studies Imdur has been shown to be well tolerated.

    Publication types

    • Review

    MeSH terms

    • Adrenergic beta-Antagonists / therapeutic use
    • Angina Pectoris / blood
    • Angina Pectoris / drug therapy*
    • Angina Pectoris / prevention & control
    • Delayed-Action Preparations
    • Drug Interactions
    • Drug Tolerance
    • Humans
    • Isosorbide Dinitrate / administration & dosage
    • Isosorbide Dinitrate / analogs & derivatives*
    • Isosorbide Dinitrate / blood
    • Isosorbide Dinitrate / therapeutic use
    • Nitroglycerin / therapeutic use


    • Adrenergic beta-Antagonists
    • Delayed-Action Preparations
    • Nitroglycerin
    • Isosorbide Dinitrate
    • isosorbide-5-mononitrate
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